Head toward Hauptbahnhof/City Center. From the airport follow the B43 for about 10km. Bear left and exit onto the B44, Kennedyallee. Cross the Main River over the Friedensbrücke. After about one kilometer, you'll see the Hauptbahnhof on the left. Turn right onto Karlstrasse. After 100m, Karlstrasse intersects with Niddasrasse. Turn left. 8 parking spaces are available in the courtyard (EUR 15,00 per day), alternatively a parking garage is located at the main railway station in close proximity.
From the airport there are many S-Bahn and other trains that travel to the Hauptbahnhof. Exit the train station through the main exit and cross the tram tracks. Bear left and turn right onto Karlstrasse (The second street after Kaiserstrasse). After 100m Karlstrasse intersects with Niddastrasse. 25Hours Hotel Frankfurt by Levi's is visible on the left.
Ticket cost EUR 4,25